1. Zolfaghari Emameh R, Kuuslahti M, Nareaho A, Sukura A, Parkkila S: Innovative molecular diagnosis of Trichinella species based on beta-carbonic anhydrase genomic sequence. Microb Biotechnol 2016, 9:172-179.https://www.ncbi.nlm.nih.gov/pubmed/26639312
2. Zolfaghari Emameh R, Barker HR, Tolvanen ME, Parkkila S, Hytonen VP: Horizontal transfer of beta-carbonic anhydrase genes from prokaryotes to protozoans, insects, and nematodes. Parasit Vectors 2016, 9:152.https://www.ncbi.nlm.nih.gov/pubmed/26983858
3. Zolfaghari Emameh R, Barker HR, Syrjanen L, Urbanski L, Supuran CT, Parkkila S: Identification and inhibition of carbonic anhydrases from nematodes. J Enzyme Inhib Med Chem 2016:1-9.https://www.ncbi.nlm.nih.gov/pubmed/27557594
4. Patrikainen MS, Pan P, Barker HR, Parkkila S: Altered gene expression in the lower respiratory tract of Car6 -/- mice. Transgenic Res 2016.https://www.ncbi.nlm.nih.gov/pubmed/27209317
5. Niinimaki E, Muola P, Parkkila S, Kholova I, Haapasalo H, Pastorekova S, Pastorek J, Paavonen T, Mennander A: Carbonic anhydrase IX deposits are associated with increased ascending aortic dilatation. Scand Cardiovasc J 2016, 50:162-166.https://www.ncbi.nlm.nih.gov/pubmed/27157093
6. Zolfaghari Emameh R, Syrjanen L, Barker H, Supuran CT, Parkkila S: Drosophila melanogaster: a model organism for controlling Dipteran vectors and pests. J Enzyme Inhib Med Chem 2015, 30:505-513.https://www.ncbi.nlm.nih.gov/pubmed/25198895
7. Zolfaghari Emameh R, Kuuslahti M, Vullo D, Barker HR, Supuran CT, Parkkila S: Ascaris lumbricoides beta carbonic anhydrase: a potential target enzyme for treatment of ascariasis. Parasit Vectors 2015, 8:479.https://www.ncbi.nlm.nih.gov/pubmed/26385556
8. Syrjanen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Ramet M, Parkkila S: beta carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool 2015, 12:19.https://www.ncbi.nlm.nih.gov/pubmed/26300950
9. Syrjanen L, Kuuslahti M, Tolvanen M, Vullo D, Parkkila S, Supuran CT: The beta-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides. Bioorg Med Chem 2015, 23:2303-2309.https://www.ncbi.nlm.nih.gov/pubmed/25882523
10. La Regina G, Coluccia A, Famiglini V, Pelliccia S, Monti L, Vullo D, Nuti E, Alterio V, De Simone G, Monti SM, et al: Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors. J Med Chem 2015, 58:8564-8572.https://www.ncbi.nlm.nih.gov/pubmed/26497049
11. Aspatwar A, Tolvanen ME, Ojanen MJ, Barker HR, Saralahti AK, Bauerlein CA, Ortutay C, Pan P, Kuuslahti M, Parikka M, et al: Inactivation of ca10a and ca10b Genes Leads to Abnormal Embryonic Development and Alters Movement Pattern in Zebrafish. PLoS One 2015, 10:e0134263.https://www.ncbi.nlm.nih.gov/pubmed/26218428
12. Alafeefy AM, Ceruso M, Al-Jaber NA, Parkkila S, Vermelho AB, Supuran CT: A new class of quinazoline-sulfonamides acting as efficient inhibitors against the alpha-carbonic anhydrase from Trypanosoma cruzi. J Enzyme Inhib Med Chem 2015, 30:581-585.https://www.ncbi.nlm.nih.gov/pubmed/25373503
13. Zolfaghari Emameh R, Barker H, Tolvanen ME, Ortutay C, Parkkila S: Bioinformatic analysis of beta carbonic anhydrase sequences from protozoans and metazoans. Parasit Vectors 2014, 7:38.https://www.ncbi.nlm.nih.gov/pubmed/24447594
14. Zolfaghari Emameh R, Barker H, Hytonen VP, Tolvanen ME, Parkkila S: Beta carbonic anhydrases: novel targets for pesticides and anti-parasitic agents in agriculture and livestock husbandry. Parasit Vectors 2014, 7:403.https://www.ncbi.nlm.nih.gov/pubmed/25174433
15. Takacova M, Bullova P, Simko V, Skvarkova L, Poturnajova M, Feketeova L, Babal P, Kivela AJ, Kuopio T, Kopacek J, et al: Expression pattern of carbonic anhydrase IX in Medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway. Am J Pathol 2014, 184:953-965.https://www.ncbi.nlm.nih.gov/pubmed/24518567
16. Syrjanen L, Parkkila S, Scozzafava A, Supuran CT: Sulfonamide inhibition studies of the beta carbonic anhydrase from Drosophila melanogaster. Bioorg Med Chem Lett 2014, 24:2797-2801.https://www.ncbi.nlm.nih.gov/pubmed/24852120
17. Syrjanen L, Luukkaala T, Leppilampi M, Kallioinen M, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S, Karttunen T: Expression of cancer-related carbonic anhydrases IX and XII in normal skin and skin neoplasms. APMIS 2014, 122:880-889.https://www.ncbi.nlm.nih.gov/pubmed/24698175
18. Rodrigues GC, Feijo DF, Bozza MT, Pan P, Vullo D, Parkkila S, Supuran CT, Capasso C, Aguiar AP, Vermelho AB: Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease. J Med Chem 2014, 57:298-308.https://www.ncbi.nlm.nih.gov/pubmed/24299463
19. Reibring CG, El Shahawy M, Hallberg K, Kannius-Janson M, Nilsson J, Parkkila S, Sly WS, Waheed A, Linde A, Gritli-Linde A: Expression patterns and subcellular localization of carbonic anhydrases are developmentally regulated during tooth formation. PLoS One 2014, 9:e96007.https://www.ncbi.nlm.nih.gov/pubmed/24789143
20. Patrikainen M, Pan P, Kulesskaya N, Voikar V, Parkkila S: The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6(-)/(-) mouse model. J Biomed Sci 2014, 21:82.https://www.ncbi.nlm.nih.gov/pubmed/25134447
21. Matthews TA, Abel A, Demme C, Sherman T, Pan PW, Halterman MW, Parkkila S, Nehrke K: Expression of the CHOP-inducible carbonic anhydrase CAVI-b is required for BDNF-mediated protection from hypoxia. Brain Res 2014, 1543:28-37.https://www.ncbi.nlm.nih.gov/pubmed/24275196
22. Makela KS, Haapasalo JA, Ilvesaro JM, Parkkila S, Paavonen T, Haapasalo HK: Hsp27 and its expression pattern in diffusely infiltrating astrocytomas. Histol Histopathol 2014, 29:1161-1168.https://www.ncbi.nlm.nih.gov/pubmed/24599602
23. Dekaminaviciute D, Lasickiene R, Parkkila S, Jogaite V, Matuliene J, Matulis D, Zvirbliene A: Development and characterization of new monoclonal antibodies against human recombinant CA XII. Biomed Res Int 2014, 2014:309307.https://www.ncbi.nlm.nih.gov/pubmed/24967350
24. Aspatwar A, Tolvanen ME, Ortutay C, Parkkila S: Carbonic anhydrase related proteins: molecular biology and evolution. Subcell Biochem 2014, 75:135-156.https://www.ncbi.nlm.nih.gov/pubmed/24146378
25. Alterio V, Pan P, Parkkila S, Buonanno M, Supuran CT, Monti SM, De Simone G: The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers 2014, 101:769-778.https://www.ncbi.nlm.nih.gov/pubmed/24374484
26. Tolvanen ME, Ortutay C, Barker HR, Aspatwar A, Patrikainen M, Parkkila S: Analysis of evolution of carbonic anhydrases IV and XV reveals a rich history of gene duplications and a new group of isozymes. Bioorg Med Chem 2013, 21:1503-1510.https://www.ncbi.nlm.nih.gov/pubmed/23022279
27. Syrjanen L, Vermelho AB, Rodrigues Ide A, Corte-Real S, Salonen T, Pan P, Vullo D, Parkkila S, Capasso C, Supuran CT: Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis. J Med Chem 2013, 56:7372-7381.https://www.ncbi.nlm.nih.gov/pubmed/23977960
28. Syrjanen L, Tolvanen ME, Hilvo M, Vullo D, Carta F, Supuran CT, Parkkila S: Characterization, bioinformatic analysis and dithiocarbamate inhibition studies of two new alpha-carbonic anhydrases, CAH1 and CAH2, from the fruit fly Drosophila melanogaster. Bioorg Med Chem 2013, 21:1516-1521.https://www.ncbi.nlm.nih.gov/pubmed/22989910
29. Pan P, Vermelho AB, Scozzafava A, Parkkila S, Capasso C, Supuran CT: Anion inhibition studies of the alpha-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease. Bioorg Med Chem 2013, 21:4472-4476.https://www.ncbi.nlm.nih.gov/pubmed/23790722
30. Pan P, Vermelho AB, Capaci Rodrigues G, Scozzafava A, Tolvanen ME, Parkkila S, Capasso C, Supuran CT: Cloning, characterization, and sulfonamide and thiol inhibition studies of an alpha-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease. J Med Chem 2013, 56:1761-1771.https://www.ncbi.nlm.nih.gov/pubmed/23391336
31. Laurila R, Parkkila S, Isola J, Kallioniemi A, Alarmo EL: The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues. Int J Clin Exp Pathol 2013, 6:1400-1408.https://www.ncbi.nlm.nih.gov/pubmed/23826422
32. Kivela AJ, Knuuttila A, Rasanen J, Sihvo E, Salmenkivi K, Saarnio J, Pastorekova S, Pastorek J, Waheed A, Sly WS, et al: Carbonic anhydrase IX in malignant pleural mesotheliomas: a potential target for anti-cancer therapy. Bioorg Med Chem 2013, 21:1483-1488.https://www.ncbi.nlm.nih.gov/pubmed/23036334
33. Kim JH, Parkkila S, Shibata S, Fujimiya M, Murakami G, Cho BH: Expression of carbonic anhydrase IX in human fetal joints, ligaments and tendons: a potential marker of mechanical stress in fetal development? Anat Cell Biol 2013, 46:272-284.https://www.ncbi.nlm.nih.gov/pubmed/24386600
34. Harju AK, Bootorabi F, Kuuslahti M, Supuran CT, Parkkila S: Carbonic anhydrase III: a neglected isozyme is stepping into the limelight. J Enzyme Inhib Med Chem 2013, 28:231-239.https://www.ncbi.nlm.nih.gov/pubmed/22803676
35. Guzel-Akdemir O, Akdemir A, Pan P, Vermelho AB, Parkkila S, Scozzafava A, Capasso C, Supuran CT: A class of sulfonamides with strong inhibitory action against the alpha-carbonic anhydrase from Trypanosoma cruzi. J Med Chem 2013, 56:5773-5781.https://www.ncbi.nlm.nih.gov/pubmed/23815159
36. Aspatwar A, Tolvanen ME, Parkkila S: An update on carbonic anhydrase-related proteins VIII, X and XI. J Enzyme Inhib Med Chem 2013, 28:1129-1142.https://www.ncbi.nlm.nih.gov/pubmed/23294106
37. Aspatwar A, Tolvanen ME, Jokitalo E, Parikka M, Ortutay C, Harjula SK, Ramet M, Vihinen M, Parkkila S: Abnormal cerebellar development and ataxia in CARP VIII morphant zebrafish. Hum Mol Genet 2013, 22:417-432.https://www.ncbi.nlm.nih.gov/pubmed/23087022
38. Alarmo EL, Huhtala H, Korhonen T, Pylkkanen L, Holli K, Kuukasjarvi T, Parkkila S, Kallioniemi A: Bone morphogenetic protein 4 expression in multiple normal and tumor tissues reveals its importance beyond development. Mod Pathol 2013, 26:10-21.https://www.ncbi.nlm.nih.gov/pubmed/22899288
39. Aidar M, Marques R, Valjakka J, Mononen N, Lehtimaki T, Parkkila S, de Souza AP, Line SR: Effect of genetic polymorphisms in CA6 gene on the expression and catalytic activity of human salivary carbonic anhydrase VI. Caries Res 2013, 47:414-420.https://www.ncbi.nlm.nih.gov/pubmed/23652931
40. Abe S, Nakao T, Yoshimoto T, Parkkila S, Murakami G, Cho BH: Expression of carbonic anhydrase in the fetal eye and extra-ocular tissues. Okajimas Folia Anat Jpn 2013, 90:59-68.https://www.ncbi.nlm.nih.gov/pubmed/24670491
41. Pertovaara M, Bootorabi F, Kuuslahti M, Uusitalo H, Pukander J, Helin H, Parkkila S: Carbonic anhydrase autoantibodies and sicca symptoms in primary Sjogren s syndrome. Clin Exp Rheumatol 2012, 30:456-457.https://www.ncbi.nlm.nih.gov/pubmed/22513263
42. Parkkila S, Vullo D, Maresca A, Carta F, Scozzafava A, Supuran CT: Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases. Chem Commun (Camb) 2012, 48:3551-3553.https://www.ncbi.nlm.nih.gov/pubmed/22382897
43. Pan PW, Parkkila AK, Autio S, Hilvo M, Sormunen R, Pastorekova S, Pastorek J, Haapasalo H, Parkkila S: Brain phenotype of carbonic anhydrase IX-deficient mice. Transgenic Res 2012, 21:163-176.https://www.ncbi.nlm.nih.gov/pubmed/21547424
44. Kontsekova S, Ohradanova Repic A, Polcicova K, Tuomaala P, Pastorek J, Pastorekova S, Parkkila S, Barathova M: Novel monoclonal antibodies specific for CTLD-SSC and sialomucin domains of endosialin, a mural cell marker of tumor vasculature. Int J Oncol 2012, 41:1365-1372.https://www.ncbi.nlm.nih.gov/pubmed/22824847
45. Hynninen P, Parkkila S, Huhtala H, Pastorekova S, Pastorek J, Waheed A, Sly WS, Tomas E: Carbonic anhydrase isozymes II, IX, and XII in uterine tumors. APMIS 2012, 120:117-129.https://www.ncbi.nlm.nih.gov/pubmed/22229267
46. Durdagi S, Vullo D, Pan P, Kahkonen N, Maatta JA, Hytonen VP, Scozzafava A, Parkkila S, Supuran CT: Protein-protein interactions: inhibition of mammalian carbonic anhydrases I-XV by the murine inhibitor of carbonic anhydrase and other members of the transferrin family. J Med Chem 2012, 55:5529-5535.https://www.ncbi.nlm.nih.gov/pubmed/22578027
47. Tothova V, Isola J, Parkkila S, Kopacek J, Pastorek J, Pastorekova S, Gibadulinova A: Glucocorticoid receptor-mediated transcriptional activation of S100P gene coding for cancer-related calcium-binding protein. J Cell Biochem 2011, 112:3373-3384.https://www.ncbi.nlm.nih.gov/pubmed/21751241
48. Pertovaara M, Bootorabi F, Kuuslahti M, Pasternack A, Parkkila S: Novel carbonic anhydrase autoantibodies and renal manifestations in patients with primary Sjogren’s syndrome. Rheumatology (Oxford) 2011, 50:1453-1457.https://www.ncbi.nlm.nih.gov/pubmed/21427176
49. Pan PW, Kayra K, Leinonen J, Nissinen M, Parkkila S, Rajaniemi H: Gene expression profiling in the submandibular gland, stomach, and duodenum of CAVI-deficient mice. Transgenic Res 2011, 20:675-698.https://www.ncbi.nlm.nih.gov/pubmed/20835760
50. Kallio H, Tolvanen M, Janis J, Pan PW, Laurila E, Kallioniemi A, Kilpinen S, Tuominen VJ, Isola J, Valjakka J, et al: Characterization of non-specific cytotoxic cell receptor protein 1: a new member of the lectin-type subfamily of F-box proteins. PLoS One 2011, 6:e27152.https://www.ncbi.nlm.nih.gov/pubmed/22087255
51. Culp DJ, Robinson B, Parkkila S, Pan PW, Cash MN, Truong HN, Hussey TW, Gullett SL: Oral colonization by Streptococcus mutans and caries development is reduced upon deletion of carbonic anhydrase VI expression in saliva. Biochim Biophys Acta 2011, 1812:1567-1576.https://www.ncbi.nlm.nih.gov/pubmed/21945428
52. Bootorabi F, Janis J, Hytonen VP, Valjakka J, Kuuslahti M, Vullo D, Niemela O, Supuran CT, Parkkila S: Acetaldehyde-derived modifications on cytosolic human carbonic anhydrases. J Enzyme Inhib Med Chem 2011, 26:862-870.https://www.ncbi.nlm.nih.gov/pubmed/21679053
53. Temperini C, Innocenti A, Scozzafava A, Parkkila S, Supuran CT: The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors. J Med Chem 2010, 53:850-854.https://www.ncbi.nlm.nih.gov/pubmed/20028100
54. Syrjanen L, Tolvanen M, Hilvo M, Olatubosun A, Innocenti A, Scozzafava A, Leppiniemi J, Niederhauser B, Hytonen VP, Gorr TA, et al: Characterization of the first beta-class carbonic anhydrase from an arthropod (Drosophila melanogaster) and phylogenetic analysis of beta-class carbonic anhydrases in invertebrates. BMC Biochem 2010, 11:28.https://www.ncbi.nlm.nih.gov/pubmed/20659325
55. Saari S, Hilvo M, Pan P, Gros G, Hanke N, Waheed A, Sly WS, Parkkila S: The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney. PLoS One 2010, 5:e9624.https://www.ncbi.nlm.nih.gov/pubmed/20224780
56. Parkkila S, Lasota J, Fletcher JA, Ou WB, Kivela AJ, Nuorva K, Parkkila AK, Ollikainen J, Sly WS, Waheed A, et al: Carbonic anhydrase II. A novel biomarker for gastrointestinal stromal tumors. Mod Pathol 2010, 23:743-750.https://www.ncbi.nlm.nih.gov/pubmed/20081808
57. Pan PW, Waheed A, Sly WS, Parkkila S: Carbonic anhydrases in the mouse harderian gland. J Mol Histol 2010, 41:411-417.https://www.ncbi.nlm.nih.gov/pubmed/20820888
58. Oksala N, Levula M, Pelto-Huikko M, Kytomaki L, Soini JT, Salenius J, Kahonen M, Karhunen PJ, Laaksonen R, Parkkila S, Lehtimaki T: Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study. Ann Med 2010, 42:360-370.https://www.ncbi.nlm.nih.gov/pubmed/20509747
59. Nordfors K, Haapasalo J, Korja M, Niemela A, Laine J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, et al: The tumour-associated carbonic anhydrases CA II, CA IX and CA XII in a group of medulloblastomas and supratentorial primitive neuroectodermal tumours: an association of CA IX with poor prognosis. BMC Cancer 2010, 10:148.https://www.ncbi.nlm.nih.gov/pubmed/20398423
60. Kallio H, Hilvo M, Rodriguez A, Lappalainen EH, Lappalainen AM, Parkkila S: Global transcriptional response to carbonic anhydrase IX deficiency in the mouse stomach. BMC Genomics 2010, 11:397.https://www.ncbi.nlm.nih.gov/pubmed/20573196
61. Jarvela S, Rantala I, Rodriguez A, Kallio H, Parkkila S, Kinnula VL, Soini Y, Haapasalo H: Specific expression profile and prognostic significance of peroxiredoxins in grade II-IV astrocytic brain tumors. BMC Cancer 2010, 10:104.https://www.ncbi.nlm.nih.gov/pubmed/20307276
62. Hallerdei J, Scheibe RJ, Parkkila S, Waheed A, Sly WS, Gros G, Wetzel P, Endeward V: T tubules and surface membranes provide equally effective pathways of carbonic anhydrase-facilitated lactic acid transport in skeletal muscle. PLoS One 2010, 5:e15137.https://www.ncbi.nlm.nih.gov/pubmed/21179203
63. Di Fiore A, Truppo E, Supuran CT, Alterio V, Dathan N, Bootorabi F, Parkkila S, Monti SM, De Simone G: Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide. Bioorg Med Chem Lett 2010, 20:5023-5026.https://www.ncbi.nlm.nih.gov/pubmed/20688517
64. Bootorabi F, Janis J, Smith E, Waheed A, Kukkurainen S, Hytonen V, Valjakka J, Supuran CT, Vullo D, Sly WS, Parkkila S: Analysis of a shortened form of human carbonic anhydrase VII expressed in vitro compared to the full-length enzyme. Biochimie 2010, 92:1072-1080.https://www.ncbi.nlm.nih.gov/pubmed/20493921
65. Baranauskiene L, Hilvo M, Matuliene J, Golovenko D, Manakova E, Dudutiene V, Michailoviene V, Torresan J, Jachno J, Parkkila S, et al: Inhibition and binding studies of carbonic anhydrase isozymes I, II and IX with benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulphonamides. J Enzyme Inhib Med Chem 2010, 25:863-870.https://www.ncbi.nlm.nih.gov/pubmed/20166809
66. Aspatwar A, Tolvanen ME, Parkkila S: Phylogeny and expression of carbonic anhydrase-related proteins. BMC Mol Biol 2010, 11:25.https://www.ncbi.nlm.nih.gov/pubmed/20356370
67. Aspatwar A, Tolvanen ME, Ortutay C, Parkkila S: Carbonic anhydrase related protein VIII and its role in neurodegeneration and cancer. Curr Pharm Des 2010, 16:3264-3276.https://www.ncbi.nlm.nih.gov/pubmed/20819067
68. Agborsangaya CB, Surcel HM, Toriola AT, Pukkala E, Parkkila S, Tuohimaa P, Lukanova A, Lehtinen M: Serum 25-hydroxyvitamin D at pregnancy and risk of breast cancer in a prospective study. Eur J Cancer 2010, 46:467-470.https://www.ncbi.nlm.nih.gov/pubmed/20022237
69. Agborsangaya C, Toriola AT, Grankvist K, Surcel HM, Holl K, Parkkila S, Tuohimaa P, Lukanova A, Lehtinen M: The effects of storage time and sampling season on the stability of serum 25-hydroxy vitamin D and androstenedione. Nutr Cancer 2010, 62:51-57.https://www.ncbi.nlm.nih.gov/pubmed/20043259
70. Rodriguez A, Luukkaala T, Fleming RE, Britton RS, Bacon BR, Parkkila S: Global transcriptional response to Hfe deficiency and dietary iron overload in mouse liver and duodenum. PLoS One 2009, 4:e7212.https://www.ncbi.nlm.nih.gov/pubmed/19787063
71. Parkkila S, Innocenti A, Kallio H, Hilvo M, Scozzafava A, Supuran CT: The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms. Bioorg Med Chem Lett 2009, 19:4102-4106.https://www.ncbi.nlm.nih.gov/pubmed/19527930
72. Korhonen K, Parkkila AK, Helen P, Valimaki R, Pastorekova S, Pastorek J, Parkkila S, Haapasalo H: Carbonic anhydrases in meningiomas: association of endothelial carbonic anhydrase II with aggressive tumor features. J Neurosurg 2009, 111:472-477.https://www.ncbi.nlm.nih.gov/pubmed/19216648
73. Innocenti A, Hilvo M, Parkkila S, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions. Bioorg Med Chem Lett 2009, 19:1155-1158.https://www.ncbi.nlm.nih.gov/pubmed/19128966
74. Innocenti A, Hilvo M, Parkkila S, Scozzafava A, Supuran CT: Carbonic anhydrase activators. Activation of the membrane-associated isoform XV with amino acids and amines. Bioorg Med Chem Lett 2009, 19:3430-3433.https://www.ncbi.nlm.nih.gov/pubmed/19464888
75. Hilvo M, Salzano AM, Innocenti A, Kulomaa MS, Scozzafava A, Scaloni A, Parkkila S, Supuran CT: Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV. J Med Chem 2009, 52:646-654.https://www.ncbi.nlm.nih.gov/pubmed/19193158
76. Hanninen MM, Haapasalo J, Haapasalo H, Fleming RE, Britton RS, Bacon BR, Parkkila S: Expression of iron-related genes in human brain and brain tumors. BMC Neurosci 2009, 10:36.https://www.ncbi.nlm.nih.gov/pubmed/19386095
77. Di Fiore A, Monti SM, Hilvo M, Parkkila S, Romano V, Scaloni A, Pedone C, Scozzafava A, Supuran CT, De Simone G: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. Proteins 2009, 74:164-175.https://www.ncbi.nlm.nih.gov/pubmed/18618712
78. Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, Scaloni A, Pastorek J, Pastorekova S, Pedone C, et al: Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc Natl Acad Sci U S A 2009, 106:16233-16238.https://www.ncbi.nlm.nih.gov/pubmed/19805286
79. Warnakulasuriya S, Parkkila S, Nagao T, Preedy VR, Pasanen M, Koivisto H, Niemela O: Demonstration of ethanol-induced protein adducts in oral leukoplakia (pre-cancer) and cancer. J Oral Pathol Med 2008, 37:157-165.https://www.ncbi.nlm.nih.gov/pubmed/18251940
80. Parkkila S, Pan PW, Ward A, Gibadulinova A, Oveckova I, Pastorekova S, Pastorek J, Martinez AR, Helin HO, Isola J: The calcium-binding protein S100P in normal and malignant human tissues. BMC Clin Pathol 2008, 8:2.https://www.ncbi.nlm.nih.gov/pubmed/18282279
81. Parkkila S: Significance of pH regulation and carbonic anhydrases in tumour progression and implications for diagnostic and therapeutic approaches. BJU Int 2008, 101 Suppl 4:16-21.https://www.ncbi.nlm.nih.gov/pubmed/18430117
82. Ohradanova A, Gradin K, Barathova M, Zatovicova M, Holotnakova T, Kopacek J, Parkkila S, Poellinger L, Pastorekova S, Pastorek J: Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2. Br J Cancer 2008, 99:1348-1356.https://www.ncbi.nlm.nih.gov/pubmed/18813310
83. Jarvela S, Parkkila S, Bragge H, Kahkonen M, Parkkila AK, Soini Y, Pastorekova S, Pastorek J, Haapasalo H: Carbonic anhydrase IX in oligodendroglial brain tumors. BMC Cancer 2008, 8:1.https://www.ncbi.nlm.nih.gov/pubmed/18173856
84. Innocenti A, Scozzafava A, Parkkila S, Puccetti L, De Simone G, Supuran CT: Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates. Bioorg Med Chem Lett 2008, 18:2267-2271.https://www.ncbi.nlm.nih.gov/pubmed/18353640
85. Innocenti A, Hilvo M, Scozzafava A, Parkkila S, Supuran CT: Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols. Bioorg Med Chem Lett 2008, 18:3593-3596.https://www.ncbi.nlm.nih.gov/pubmed/18501600
86. Innocenti A, Hilvo M, Scozzafava A, Lindfors M, Nordlund HR, Kulomaa MS, Parkkila S, Supuran CT: Carbonic anhydrase inhibitors: the very weak inhibitors dithiothreitol, beta-mercaptoethanol, tris(carboxyethyl)phosphine and threitol interfere with the binding of sulfonamides to isozymes II and IX. Bioorg Med Chem Lett 2008, 18:1898-1903.https://www.ncbi.nlm.nih.gov/pubmed/18295485
87. Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S: Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV. Curr Pharm Des 2008, 14:672-678.https://www.ncbi.nlm.nih.gov/pubmed/18336313
88. Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, et al: Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J Biol Chem 2008, 283:27799-27809.https://www.ncbi.nlm.nih.gov/pubmed/18703501
89. Haapasalo J, Hilvo M, Nordfors K, Haapasalo H, Parkkila S, Hyrskyluoto A, Rantala I, Waheed A, Sly WS, Pastorekova S, et al: Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas. Neuro Oncol 2008, 10:131-138.https://www.ncbi.nlm.nih.gov/pubmed/18322268
90. Guzel O, Innocenti A, Scozzafava A, Salman A, Parkkila S, Hilvo M, Supuran CT: Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides. Bioorg Med Chem 2008, 16:9113-9120.https://www.ncbi.nlm.nih.gov/pubmed/18819811
91. Gibadulinova A, Oveckova I, Parkkila S, Pastorekova S, Pastorek J: Key promoter elements involved in transcriptional activation of the cancer-related gene coding for S100P calcium-binding protein. Oncol Rep 2008, 20:391-396.https://www.ncbi.nlm.nih.gov/pubmed/18636203
92. Bootorabi F, Janis J, Valjakka J, Isoniemi S, Vainiotalo P, Vullo D, Supuran CT, Waheed A, Sly WS, Niemela O, Parkkila S: Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity. BMC Biochem 2008, 9:32.https://www.ncbi.nlm.nih.gov/pubmed/19036170
93. Barathova M, Takacova M, Holotnakova T, Gibadulinova A, Ohradanova A, Zatovicova M, Hulikova A, Kopacek J, Parkkila S, Supuran CT, et al: Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype. Br J Cancer 2008, 98:129-136.https://www.ncbi.nlm.nih.gov/pubmed/18026188
94. Wong MC, Portmann B, Sherwood R, Niemela O, Koivisto H, Parkkila S, Trick K, L’Abbe M R, Wilson J, Dash PR, et al: The cytoprotective effect of alpha-tocopherol and daidzein against d-galactosamine-induced oxidative damage in the rat liver. Metabolism 2007, 56:865-875.https://www.ncbi.nlm.nih.gov/pubmed/17570244
95. Takacova M, Barathova M, Hulikova A, Ohradanova A, Kopacek J, Parkkila S, Pastorek J, Pastorekova S, Zatovicova M: Hypoxia-inducible expression of the mouse carbonic anhydrase IX demonstrated by new monoclonal antibodies. Int J Oncol 2007, 31:1103-1110.https://www.ncbi.nlm.nih.gov/pubmed/17912436
96. Rodriguez A, Pan P, Parkkila S: Expression studies of neogenin and its ligand hemojuvelin in mouse tissues. J Histochem Cytochem 2007, 55:85-96.https://www.ncbi.nlm.nih.gov/pubmed/16982849
97. Rodriguez A, Hilvo M, Kytomaki L, Fleming RE, Britton RS, Bacon BR, Parkkila S: Effects of iron loading on muscle: genome-wide mRNA expression profiling in the mouse. BMC Genomics 2007, 8:379.https://www.ncbi.nlm.nih.gov/pubmed/17949489
98. Riihonen R, Supuran CT, Parkkila S, Pastorekova S, Vaananen HK, Laitala-Leinonen T: Membrane-bound carbonic anhydrases in osteoclasts. Bone 2007, 40:1021-1031.https://www.ncbi.nlm.nih.gov/pubmed/17291844
99. Pan PW, Rodriguez A, Parkkila S: A systematic quantification of carbonic anhydrase transcripts in the mouse digestive system. BMC Mol Biol 2007, 8:22.https://www.ncbi.nlm.nih.gov/pubmed/17362527
100. Niemela AM, Hynninen P, Mecklin JP, Kuopio T, Kokko A, Aaltonen L, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, et al: Carbonic anhydrase IX is highly expressed in hereditary nonpolyposis colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007, 16:1760-1766.https://www.ncbi.nlm.nih.gov/pubmed/17855694
101. Hilvo M, Supuran CT, Parkkila S: Characterization and inhibition of the recently discovered carbonic anhydrase isoforms CA XIII, XIV and XV. Curr Top Med Chem 2007, 7:893-899.https://www.ncbi.nlm.nih.gov/pubmed/17504134
102. Haapasalo J, Nordfors K, Jarvela S, Bragge H, Rantala I, Parkkila AK, Haapasalo H, Parkkila S: Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy. Neuro Oncol 2007, 9:308-313.https://www.ncbi.nlm.nih.gov/pubmed/17435181
103. Scheibe RJ, Gros G, Parkkila S, Waheed A, Grubb JH, Shah GN, Sly WS, Wetzel P: Expression of membrane-bound carbonic anhydrases IV, IX, and XIV in the mouse heart. J Histochem Cytochem 2006, 54:1379-1391.https://www.ncbi.nlm.nih.gov/pubmed/16924128
104. Pastorekova S, Parkkila S, Zavada J: Tumor-associated carbonic anhydrases and their clinical significance. Adv Clin Chem 2006, 42:167-216.https://www.ncbi.nlm.nih.gov/pubmed/17131627
105. Parkkila S, Vullo D, Puccetti L, Parkkila AK, Scozzafava A, Supuran CT: Carbonic anhydrase activators: activation of isozyme XIII with amino acids and amines. Bioorg Med Chem Lett 2006, 16:3955-3959.https://www.ncbi.nlm.nih.gov/pubmed/16730978
106. Pan P, Leppilampi M, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S: Carbonic anhydrase gene expression in CA II-deficient (Car2-/-) and CA IX-deficient (Car9-/-) mice. J Physiol 2006, 571:319-327.https://www.ncbi.nlm.nih.gov/pubmed/16396925
107. Koivisto H, Hietala J, Anttila P, Parkkila S, Niemela O: Long-term ethanol consumption and macrocytosis: diagnostic and pathogenic implications. J Lab Clin Med 2006, 147:191-196.https://www.ncbi.nlm.nih.gov/pubmed/16581347
108. Kallio H, Pastorekova S, Pastorek J, Waheed A, Sly WS, Mannisto S, Heikinheimo M, Parkkila S: Expression of carbonic anhydrases IX and XII during mouse embryonic development. BMC Dev Biol 2006, 6:22.https://www.ncbi.nlm.nih.gov/pubmed/16719910
109. Hynninen P, Vaskivuo L, Saarnio J, Haapasalo H, Kivela J, Pastorekova S, Pastorek J, Waheed A, Sly WS, Puistola U, Parkkila S: Expression of transmembrane carbonic anhydrases IX and XII in ovarian tumours. Histopathology 2006, 49:594-602.https://www.ncbi.nlm.nih.gov/pubmed/17163844
110. Halmi P, Parkkila S, Honkaniemi J: Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus. Neurochem Int 2006, 48:24-30.https://www.ncbi.nlm.nih.gov/pubmed/16271802
111. Haapasalo JA, Nordfors KM, Hilvo M, Rantala IJ, Soini Y, Parkkila AK, Pastorekova S, Pastorek J, Parkkila SM, Haapasalo HK: Expression of carbonic anhydrase IX in astrocytic tumors predicts poor prognosis. Clin Cancer Res 2006, 12:473-477.https://www.ncbi.nlm.nih.gov/pubmed/16428489
112. Leppilampi M, Parkkila S, Karttunen T, Gut MO, Gros G, Sjoblom M: Carbonic anhydrase isozyme-II-deficient mice lack the duodenal bicarbonate secretory response to prostaglandin E2. Proc Natl Acad Sci U S A 2005, 102:15247-15252.https://www.ncbi.nlm.nih.gov/pubmed/16217040
113. Leppilampi M, Karttunen TJ, Kivela J, Gut MO, Pastorekova S, Pastorek J, Parkkila S: Gastric pit cell hyperplasia and glandular atrophy in carbonic anhydrase IX knockout mice: studies on two strains C57/BL6 and BALB/C. Transgenic Res 2005, 14:655-663.https://www.ncbi.nlm.nih.gov/pubmed/16245156
114. Kummola L, Hamalainen JM, Kivela J, Kivela AJ, Saarnio J, Karttunen T, Parkkila S: Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa. BMC Cancer 2005, 5:41.https://www.ncbi.nlm.nih.gov/pubmed/15836783
115. Kleinke T, Wagner S, John H, Hewett-Emmett D, Parkkila S, Forssmann WG, Gros G: A distinct carbonic anhydrase in the mucus of the colon of humans and other mammals. J Exp Biol 2005, 208:487-496.https://www.ncbi.nlm.nih.gov/pubmed/15671337
116. Kivela AJ, Parkkila S, Saarnio J, Karttunen TJ, Kivela J, Parkkila AK, Bartosova M, Mucha V, Novak M, Waheed A, et al: Expression of von Hippel-Lindau tumor suppressor and tumor-associated carbonic anhydrases IX and XII in normal and neoplastic colorectal mucosa. World J Gastroenterol 2005, 11:2616-2625.https://www.ncbi.nlm.nih.gov/pubmed/15849821
117. Kivela AJ, Kivela J, Saarnio J, Parkkila S: Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours. World J Gastroenterol 2005, 11:155-163.https://www.ncbi.nlm.nih.gov/pubmed/15633208
118. Hilvo M, Tolvanen M, Clark A, Shen B, Shah GN, Waheed A, Halmi P, Hanninen M, Hamalainen JM, Vihinen M, et al: Characterization of CA XV, a new GPI-anchored form of carbonic anhydrase. Biochem J 2005, 392:83-92.https://www.ncbi.nlm.nih.gov/pubmed/16083424
119. Hannuksela J, Leppilampi M, Peuhkurinen K, Karkkainen S, Saastamoinen E, Helio T, Kaartinen M, Nieminen MS, Nieminen P, Parkkila S: Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy. Eur J Heart Fail 2005, 7:103-108.https://www.ncbi.nlm.nih.gov/pubmed/15642540
120. Freeman TL, Tuma DJ, Thiele GM, Klassen LW, Worrall S, Niemela O, Parkkila S, Emery PW, Preedy VR: Recent advances in alcohol-induced adduct formation. Alcohol Clin Exp Res 2005, 29:1310-1316.https://www.ncbi.nlm.nih.gov/pubmed/16088993
121. Rodriguez Martinez A, Niemela O, Parkkila S: Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. Haematologica 2004, 89:1441-1445.https://www.ncbi.nlm.nih.gov/pubmed/15590393
122. Pastorekova S, Parkkila S, Pastorek J, Supuran CT: Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J Enzyme Inhib Med Chem 2004, 19:199-229.https://www.ncbi.nlm.nih.gov/pubmed/15499993
123. Niemela O, Parkkila S: Alcoholic macrocytosis–is there a role for acetaldehyde and adducts? Addict Biol 2004, 9:3-10.https://www.ncbi.nlm.nih.gov/pubmed/15203433
124. Lehtonen JM, Parkkila S, Vullo D, Casini A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Inhibition of cytosolic isozyme XIII with aromatic and heterocyclic sulfonamides: a novel target for the drug design. Bioorg Med Chem Lett 2004, 14:3757-3762.https://www.ncbi.nlm.nih.gov/pubmed/15203157
125. Lehtonen J, Shen B, Vihinen M, Casini A, Scozzafava A, Supuran CT, Parkkila AK, Saarnio J, Kivela AJ, Waheed A, et al: Characterization of CA XIII, a novel member of the carbonic anhydrase isozyme family. J Biol Chem 2004, 279:2719-2727.https://www.ncbi.nlm.nih.gov/pubmed/14600151
126. Latvala J, Parkkila S, Niemela O: Excess alcohol consumption is common in patients with cytopenia: studies in blood and bone marrow cells. Alcohol Clin Exp Res 2004, 28:619-624.https://www.ncbi.nlm.nih.gov/pubmed/15100613
127. Innocenti A, Lehtonen JM, Parkkila S, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett 2004, 14:5435-5439.https://www.ncbi.nlm.nih.gov/pubmed/15454240
128. Hynninen P, Hamalainen JM, Pastorekova S, Pastorek J, Waheed A, Sly WS, Tomas E, Kirkinen P, Parkkila S: Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs. Reprod Biol Endocrinol 2004, 2:73.https://www.ncbi.nlm.nih.gov/pubmed/15488153
129. Hilvo M, Rafajova M, Pastorekova S, Pastorek J, Parkkila S: Expression of carbonic anhydrase IX in mouse tissues. J Histochem Cytochem 2004, 52:1313-1322.https://www.ncbi.nlm.nih.gov/pubmed/15385577
130. Halmi P, Lehtonen J, Waheed A, Sly WS, Parkkila S: Expression of hypoxia-inducible, membrane-bound carbonic anhydrase isozyme XII in mouse tissues. Anat Rec A Discov Mol Cell Evol Biol 2004, 277:171-177.https://www.ncbi.nlm.nih.gov/pubmed/14983512
131. Zat’ovicova M, Tarabkova K, Svastova E, Gibadulinova A, Mucha V, Jakubickova L, Biesova Z, Rafajova M, Ortova Gut M, Parkkila S, et al: Monoclonal antibodies generated in carbonic anhydrase IX-deficient mice recognize different domains of tumour-associated hypoxia-induced carbonic anhydrase IX. J Immunol Methods 2003, 282:117-134.https://www.ncbi.nlm.nih.gov/pubmed/14604546
132. Niemela O, Parkkila S, Worrall S, Emery PW, Preedy VR: Generation of aldehyde-derived protein modifications in ethanol-exposed heart. Alcohol Clin Exp Res 2003, 27:1987-1992.https://www.ncbi.nlm.nih.gov/pubmed/14691387
133. Leppilampi M, Saarnio J, Karttunen TJ, Kivela J, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S: Carbonic anhydrase isozymes IX and XII in gastric tumors. World J Gastroenterol 2003, 9:1398-1403.https://www.ncbi.nlm.nih.gov/pubmed/12854129
134. Kyllonen MS, Parkkila S, Rajaniemi H, Waheed A, Grubb JH, Shah GN, Sly WS, Kaunisto K: Localization of carbonic anhydrase XII to the basolateral membrane of H+-secreting cells of mouse and rat kidney. J Histochem Cytochem 2003, 51:1217-1224.https://www.ncbi.nlm.nih.gov/pubmed/12923247
135. Kivela J, Laine M, Parkkila S, Rajaniemi H: Salivary carbonic anhydrase VI and its relation to salivary flow rate and buffer capacity in pregnant and non-pregnant women. Arch Oral Biol 2003, 48:547-551.https://www.ncbi.nlm.nih.gov/pubmed/12828982
136. Hannuksela J, Parkkila S, Waheed A, Britton RS, Fleming RE, Bacon BR, Sly WS: Human platelets express hemochromatosis protein (HFE) and transferrin receptor 2. Eur J Haematol 2003, 70:201-206.https://www.ncbi.nlm.nih.gov/pubmed/12656741
137. Hannuksela J, Niemela O, Leppilampi M, Parkkila AK, Koistinen P, Nieminen P, Parkkila S: Clinical utility and outcome of HFE-genotyping in the search for hereditary hemochromatosis. Clin Chim Acta 2003, 331:61-67.https://www.ncbi.nlm.nih.gov/pubmed/12691865
138. Chrastina A, Zavada J, Parkkila S, Kaluz S, Kaluzova M, Rajcani J, Pastorek J, Pastorekova S: Biodistribution and pharmacokinetics of 125I-labeled monoclonal antibody M75 specific for carbonic anhydrase IX, an intrinsic marker of hypoxia, in nude mice xenografted with human colorectal carcinoma. Int J Cancer 2003, 105:873-881.https://www.ncbi.nlm.nih.gov/pubmed/12767076
139. Preedy VR, Adachi J, Asano M, Koll M, Mantle D, Niemela O, Parkkila S, Paice AG, Peters T, Rajendram R, et al: Free radicals in alcoholic myopathy: indices of damage and preventive studies. Free Radic Biol Med 2002, 32:683-687.https://www.ncbi.nlm.nih.gov/pubmed/11937294
140. Parkkila S, Kivela AJ, Kaunisto K, Parkkila AK, Hakkola J, Rajaniemi H, Waheed A, Sly WS: The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV. BMC Gastroenterol 2002, 2:13.https://www.ncbi.nlm.nih.gov/pubmed/12033992
141. Niemela O, Parkkila S, Koll M, Preedy VR: Generation of protein adducts with malondialdehyde and acetaldehyde in muscles with predominantly type I or type II fibers in rats exposed to ethanol and the acetaldehyde dehydrogenase inhibitor cyanamide. Am J Clin Nutr 2002, 76:668-674.https://www.ncbi.nlm.nih.gov/pubmed/12198016
142. Niemela O, Parkkila S, Bradford B, Iimuro Y, Pasanen M, Thurman RG: Effect of Kupffer cell inactivation on ethanol-induced protein adducts in the liver. Free Radic Biol Med 2002, 33:350-355.https://www.ncbi.nlm.nih.gov/pubmed/12126756
143. Leppilampi M, Koistinen P, Savolainen ER, Hannuksela J, Parkkila AK, Niemela O, Pastorekova S, Pastorek J, Waheed A, Sly WS, et al: The expression of carbonic anhydrase II in hematological malignancies. Clin Cancer Res 2002, 8:2240-2245.https://www.ncbi.nlm.nih.gov/pubmed/12114426
144. Kaunisto K, Parkkila S, Rajaniemi H, Waheed A, Grubb J, Sly WS: Carbonic anhydrase XIV: luminal expression suggests key role in renal acidification. Kidney Int 2002, 61:2111-2118.https://www.ncbi.nlm.nih.gov/pubmed/12028451
145. Hannuksela J, Savolainen ER, Koistinen P, Parkkila S: Prevalence of HFE genotypes, C282Y and H63D, in patients with hematologic disorders. Haematologica 2002, 87:131-135.https://www.ncbi.nlm.nih.gov/pubmed/11836162
146. Halsted CH, Villanueva JA, Devlin AM, Niemela O, Parkkila S, Garrow TA, Wallock LM, Shigenaga MK, Melnyk S, James SJ: Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A 2002, 99:10072-10077.https://www.ncbi.nlm.nih.gov/pubmed/12122204
147. Gut MO, Parkkila S, Vernerova Z, Rohde E, Zavada J, Hocker M, Pastorek J, Karttunen T, Gibadulinova A, Zavadova Z, et al: Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology 2002, 123:1889-1903.https://www.ncbi.nlm.nih.gov/pubmed/12454846
148. Britton RS, Fleming RE, Parkkila S, Waheed A, Sly WS, Bacon BR: Pathogenesis of hereditary hemochromatosis: genetics and beyond. Semin Gastrointest Dis 2002, 13:68-79.https://www.ncbi.nlm.nih.gov/pubmed/12064862
149. Bartosova M, Parkkila S, Pohlodek K, Karttunen TJ, Galbavy S, Mucha V, Harris AL, Pastorek J, Pastorekova S: Expression of carbonic anhydrase IX in breast is associated with malignant tissues and is related to overexpression of c-erbB2. J Pathol 2002, 197:314-321.https://www.ncbi.nlm.nih.gov/pubmed/12115877
150. Worrall S, Niemela O, Parkkila S, Peters TJ, Preedy VR: Protein adducts in type I and type II fibre predominant muscles of the ethanol-fed rat: preferential localisation in the sarcolemmal and subsarcolemmal region. Eur J Clin Invest 2001, 31:723-730.https://www.ncbi.nlm.nih.gov/pubmed/11473574
151. Saarnio J, Parkkila S, Parkkila AK, Pastorekova S, Haukipuro K, Pastorek J, Juvonen T, Karttunen TJ: Transmembrane carbonic anhydrase, MN/CA IX, is a potential biomarker for biliary tumours. J Hepatol 2001, 35:643-649.https://www.ncbi.nlm.nih.gov/pubmed/11690711
152. Preedy VR, Adachi J, Peters TJ, Worrall S, Parkkila S, Niemela O, Asamo M, Ueno Y, Takeda K, Yamauchi M, et al: Recent advances in the pathology of alcoholic myopathy. Alcohol Clin Exp Res 2001, 25:54S-59S.https://www.ncbi.nlm.nih.gov/pubmed/11391050
153. Parkkila S, Parkkila AK, Rajaniemi H, Shah GN, Grubb JH, Waheed A, Sly WS: Expression of membrane-associated carbonic anhydrase XIV on neurons and axons in mouse and human brain. Proc Natl Acad Sci U S A 2001, 98:1918-1923.https://www.ncbi.nlm.nih.gov/pubmed/11172051
154. Parkkila S, Niemela O, Savolainen ER, Koistinen P: HFE mutations do not account for transfusional iron overload in patients with acute myeloid leukemia. Transfusion 2001, 41:828-831.https://www.ncbi.nlm.nih.gov/pubmed/11399828
155. Parkkila S, Niemela O, Britton RS, Fleming RE, Waheed A, Bacon BR, Sly WS: Molecular aspects of iron absorption and HFE expression. Gastroenterology 2001, 121:1489-1496.https://www.ncbi.nlm.nih.gov/pubmed/11729128
156. Makkonen K, Viitala KI, Parkkila S, Niemela O: Serum IgG and IgE antibodies against mold-derived antigens in patients with symptoms of hypersensitivity. Clin Chim Acta 2001, 305:89-98.https://www.ncbi.nlm.nih.gov/pubmed/11249927
157. Leinonen J, Parkkila S, Kaunisto K, Koivunen P, Rajaniemi H: Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner’s glands. J Histochem Cytochem 2001, 49:657-662.https://www.ncbi.nlm.nih.gov/pubmed/11304804
158. Latvala J, Parkkila S, Melkko J, Niemela O: Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities. Mol Med 2001, 7:401-405.https://www.ncbi.nlm.nih.gov/pubmed/11474133
159. Latvala J, Melkko J, Parkkila S, Jarvi K, Makkonen K, Niemela O: Assays for acetaldehyde-derived adducts in blood proteins based on antibodies against acetaldehyde/lipoprotein condensates. Alcohol Clin Exp Res 2001, 25:1648-1653.https://www.ncbi.nlm.nih.gov/pubmed/11707639
160. Karhumaa P, Leinonen J, Parkkila S, Kaunisto K, Tapanainen J, Rajaniemi H: The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk. Proc Natl Acad Sci U S A 2001, 98:11604-11608.https://www.ncbi.nlm.nih.gov/pubmed/11553764
161. Karhumaa P, Kaunisto K, Parkkila S, Waheed A, Pastorekova S, Pastorek J, Sly WS, Rajaniemi H: Expression of the transmembrane carbonic anhydrases, CA IX and CA XII, in the human male excurrent ducts. Mol Hum Reprod 2001, 7:611-616.https://www.ncbi.nlm.nih.gov/pubmed/11420383
162. Rintala J, Jaatinen P, Parkkila S, Sarviharju M, Kiianmaa K, Hervonen A, Niemela O: Evidence of acetaldehyde-protein adduct formation in rat brain after lifelong consumption of ethanol. Alcohol Alcohol 2000, 35:458-463.https://www.ncbi.nlm.nih.gov/pubmed/11022020
163. Parkkila S, Rajaniemi H, Parkkila AK, Kivela J, Waheed A, Pastorekova S, Pastorek J, Sly WS: Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells in vitro. Proc Natl Acad Sci U S A 2000, 97:2220-2224.https://www.ncbi.nlm.nih.gov/pubmed/10688890
164. Parkkila S, Parkkila AK, Waheed A, Britton RS, Zhou XY, Fleming RE, Tomatsu S, Bacon BR, Sly WS: Cell surface expression of HFE protein in epithelial cells, macrophages, and monocytes. Haematologica 2000, 85:340-345.https://www.ncbi.nlm.nih.gov/pubmed/10756356
165. Parkkila S, Parkkila AK, Saarnio J, Kivela J, Karttunen TJ, Kaunisto K, Waheed A, Sly WS, Tureci O, Virtanen I, Rajaniemi H: Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors. J Histochem Cytochem 2000, 48:1601-1608.https://www.ncbi.nlm.nih.gov/pubmed/11101628
166. Parkkila S: Roles of carbonic anhydrases in the alimentary tract. EXS 2000:462-474.https://www.ncbi.nlm.nih.gov/pubmed/11268530
167. Parkkila S: An overview of the distribution and function of carbonic anhydrase in mammals. EXS 2000:79-93.https://www.ncbi.nlm.nih.gov/pubmed/11268539
168. Parkkila S: [Hereditary hemochromatosis]. Duodecim 2000, 116:829-836.https://www.ncbi.nlm.nih.gov/pubmed/11787126
169. Niemela O, Parkkila S, Juvonen RO, Viitala K, Gelboin HV, Pasanen M: Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. J Hepatol 2000, 33:893-901.https://www.ncbi.nlm.nih.gov/pubmed/11131450
170. Kivela J, Parkkila S, Parkkila AK, Rajaniemi H: [Carbonic anhydrases protect teeth and upper gastrointestinal mucosa]. Duodecim 2000, 116:2105-2109.https://www.ncbi.nlm.nih.gov/pubmed/12017731
171. Kivela AJ, Parkkila S, Saarnio J, Karttunen TJ, Kivela J, Parkkila AK, Pastorekova S, Pastorek J, Waheed A, Sly WS, Rajaniemi H: Expression of transmembrane carbonic anhydrase isoenzymes IX and XII in normal human pancreas and pancreatic tumours. Histochem Cell Biol 2000, 114:197-204.https://www.ncbi.nlm.nih.gov/pubmed/11083462
172. Kivela A, Parkkila S, Saarnio J, Karttunen TJ, Kivela J, Parkkila AK, Waheed A, Sly WS, Grubb JH, Shah G, et al: Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors. Am J Pathol 2000, 156:577-584.https://www.ncbi.nlm.nih.gov/pubmed/10666387
173. Karhumaa P, Parkkila S, Waheed A, Parkkila AK, Kaunisto K, Tucker PW, Huang CJ, Sly WS, Rajaniemi H: Nuclear NonO/p54(nrb) protein is a nonclassical carbonic anhydrase. J Biol Chem 2000, 275:16044-16049.https://www.ncbi.nlm.nih.gov/pubmed/10821857
174. Karhumaa P, Parkkila S, Tureci O, Waheed A, Grubb JH, Shah G, Parkkila A, Kaunisto K, Tapanainen J, Sly WS, Rajaniemi H: Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium. Mol Hum Reprod 2000, 6:68-74.https://www.ncbi.nlm.nih.gov/pubmed/10611263
175. Jokelainen K, Parkkila S, Salaspuro M, Niemela O: Covalent adducts of proteins with acetaldehyde in the liver as a result of acetaldehyde administration in drinking water. J Hepatol 2000, 33:926-932.https://www.ncbi.nlm.nih.gov/pubmed/11131454
176. Ghandour MS, Parkkila AK, Parkkila S, Waheed A, Sly WS: Mitochondrial carbonic anhydrase in the nervous system: expression in neuronal and glial cells. J Neurochem 2000, 75:2212-2220.https://www.ncbi.nlm.nih.gov/pubmed/11032910
177. Waheed A, Parkkila S, Saarnio J, Fleming RE, Zhou XY, Tomatsu S, Britton RS, Bacon BR, Sly WS: Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci U S A 1999, 96:1579-1584.https://www.ncbi.nlm.nih.gov/pubmed/9990067
178. Satta J, Ahonen A, Parkkila S, Leinonen L, Apaja-Sarkkinen M, Lepojarvi M, Juvonen T: Multiple endocrine neoplastic-associated thymic carcinoid tumour in close relatives: octreotide scan as a new diagnostic and follow-up modality. Two case reports. Scand Cardiovasc J 1999, 33:49-53.https://www.ncbi.nlm.nih.gov/pubmed/10093860
179. Saarnio J, Parkkila S, Parkkila AK, Waheed A, Karttunen T, Sly WS: Cell-specific expression of mitochondrial carbonic anhydrase in the human and rat gastrointestinal tract. J Histochem Cytochem 1999, 47:517-524.https://www.ncbi.nlm.nih.gov/pubmed/10082753
180. Parkkila S, Halsted CH, Villanueva JA, Vaananen HK, Niemela O: Expression of testosterone-dependent enzyme, carbonic anhydrase III, and oxidative stress in experimental alcoholic liver disease. Dig Dis Sci 1999, 44:2205-2213.https://www.ncbi.nlm.nih.gov/pubmed/10573363
181. Niemela O, Parkkila S, Pasanen M, Viitala K, Villanueva JA, Halsted CH: Induction of cytochrome P450 enzymes and generation of protein-aldehyde adducts are associated with sex-dependent sensitivity to alcohol-induced liver disease in micropigs. Hepatology 1999, 30:1011-1017.https://www.ncbi.nlm.nih.gov/pubmed/10498654
182. Niemela O, Parkkila S, Britton RS, Brunt E, Janney C, Bacon B: Hepatic lipid peroxidation in hereditary hemochromatosis and alcoholic liver injury. J Lab Clin Med 1999, 133:451-460.https://www.ncbi.nlm.nih.gov/pubmed/10235128
183. Leinonen J, Kivela J, Parkkila S, Parkkila AK, Rajaniemi H: Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle. Caries Res 1999, 33:185-190.https://www.ncbi.nlm.nih.gov/pubmed/10207193
184. Kivela J, Parkkila S, Parkkila AK, Rajaniemi H: A low concentration of carbonic anhydrase isoenzyme VI in whole saliva is associated with caries prevalence. Caries Res 1999, 33:178-184.https://www.ncbi.nlm.nih.gov/pubmed/10207192
185. Kivela J, Parkkila S, Parkkila AK, Leinonen J, Rajaniemi H: Salivary carbonic anhydrase isoenzyme VI. J Physiol 1999, 520 Pt 2:315-320.https://www.ncbi.nlm.nih.gov/pubmed/10523402
186. Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed A, Jiang J, Fei Y, Brunt EM, Ruddy DA, Prass CE, et al: HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A 1998, 95:2492-2497.https://www.ncbi.nlm.nih.gov/pubmed/9482913
187. Satta J, Laurila A, Paakko P, Haukipuro K, Sormunen R, Parkkila S, Juvonen T: Chronic inflammation and elastin degradation in abdominal aortic aneurysm disease: an immunohistochemical and electron microscopic study. Eur J Vasc Endovasc Surg 1998, 15:313-319.https://www.ncbi.nlm.nih.gov/pubmed/9610343
188. Saarnio J, Parkkila S, Parkkila AK, Waheed A, Casey MC, Zhou XY, Pastorekova S, Pastorek J, Karttunen T, Haukipuro K, et al: Immunohistochemistry of carbonic anhydrase isozyme IX (MN/CA IX) in human gut reveals polarized expression in the epithelial cells with the highest proliferative capacity. J Histochem Cytochem 1998, 46:497-504.https://www.ncbi.nlm.nih.gov/pubmed/9524195
189. Saarnio J, Parkkila S, Parkkila AK, Haukipuro K, Pastorekova S, Pastorek J, Kairaluoma MI, Karttunen TJ: Immunohistochemical study of colorectal tumors for expression of a novel transmembrane carbonic anhydrase, MN/CA IX, with potential value as a marker of cell proliferation. Am J Pathol 1998, 153:279-285.https://www.ncbi.nlm.nih.gov/pubmed/9665489
190. Parkkila AK, Scarim AL, Parkkila S, Waheed A, Corbett JA, Sly WS: Expression of carbonic anhydrase V in pancreatic beta cells suggests role for mitochondrial carbonic anhydrase in insulin secretion. J Biol Chem 1998, 273:24620-24623.https://www.ncbi.nlm.nih.gov/pubmed/9733757
191. Niemela O, Parkkila S, Pasanen M, Iimuro Y, Bradford B, Thurman RG: Early alcoholic liver injury: formation of protein adducts with acetaldehyde and lipid peroxidation products, and expression of CYP2E1 and CYP3A. Alcohol Clin Exp Res 1998, 22:2118-2124.https://www.ncbi.nlm.nih.gov/pubmed/9884160
192. Waheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchihashi Z, Feder JN, Schatzman RC, Britton RS, Bacon BR, Sly WS: Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci U S A 1997, 94:12384-12389.https://www.ncbi.nlm.nih.gov/pubmed/9356458
193. Pastorekova S, Parkkila S, Parkkila AK, Opavsky R, Zelnik V, Saarnio J, Pastorek J: Carbonic anhydrase IX, MN/CA IX: analysis of stomach complementary DNA sequence and expression in human and rat alimentary tracts. Gastroenterology 1997, 112:398-408.https://www.ncbi.nlm.nih.gov/pubmed/9024293
194. Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchihashi Z, Schatzman RC, Bacon BR, Sly WS: Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci U S A 1997, 94:2534-2539.https://www.ncbi.nlm.nih.gov/pubmed/9122230
195. Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, Fleming RE, Sly WS: Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci U S A 1997, 94:13198-13202.https://www.ncbi.nlm.nih.gov/pubmed/9371823
196. Parkkila S, Parkkila AK, Lehtola J, Reinila A, Sodervik HJ, Rannisto M, Rajaniemi H: Salivary carbonic anhydrase protects gastroesophageal mucosa from acid injury. Dig Dis Sci 1997, 42:1013-1019.https://www.ncbi.nlm.nih.gov/pubmed/9149056
197. Parkkila AK, Parkkila S, Reunanen M, Niemela O, Tuisku S, Rautakorpi I, Rajaniemi H: Carbonic anhydrase II in the cerebrospinal fluid: its value as a disease marker. Eur J Clin Invest 1997, 27:392-397.https://www.ncbi.nlm.nih.gov/pubmed/9179546
198. Kivela J, Parkkila S, Waheed A, Parkkila AK, Sly WS, Rajaniemi H: Secretory carbonic anhydrase isoenzyme (CA VI) in human serum. Clin Chem 1997, 43:2318-2322.https://www.ncbi.nlm.nih.gov/pubmed/9439449
199. Kivela J, Parkkila S, Metteri J, Parkkila AK, Toivanen A, Rajaniemi H: Salivary carbonic anhydrase VI concentration and its relation to basic characteristics of saliva in young men. Acta Physiol Scand 1997, 161:221-225.https://www.ncbi.nlm.nih.gov/pubmed/9366965
200. Feder JN, Tsuchihashi Z, Irrinki A, Lee VK, Mapa FA, Morikang E, Prass CE, Starnes SM, Wolff RK, Parkkila S, et al: The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem 1997, 272:14025-14028.https://www.ncbi.nlm.nih.gov/pubmed/9162021
201. Parkkila S, Parkkila AK, Juvonen T, Waheed A, Sly WS, Saarnio J, Kaunisto K, Kellokumpu S, Rajaniemi H: Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epithelium. Hepatology 1996, 24:1104-1108.https://www.ncbi.nlm.nih.gov/pubmed/8903383
202. Parkkila S, Parkkila AK: [ Gastrointestinal carbonic anhydrases]. Duodecim 1996, 112:2383-2388.https://www.ncbi.nlm.nih.gov/pubmed/10605239
203. Parkkila S, Parkkila AK: Carbonic anhydrase in the alimentary tract. Roles of the different isozymes and salivary factors in the maintenance of optimal conditions in the gastrointestinal canal. Scand J Gastroenterol 1996, 31:305-317.https://www.ncbi.nlm.nih.gov/pubmed/8726296
204. Parkkila S, Niemela O, Britton RS, Brown KE, Yla-Herttuala S, O’Neill R, Bacon BR: Vitamin E decreases hepatic levels of aldehyde-derived peroxidation products in rats with iron overload. Am J Physiol 1996, 270:G376-384.https://www.ncbi.nlm.nih.gov/pubmed/8779982
205. Parkkila S, Ahonen A, Leinonen L, Salmela P: [Scintigraphy detection of somatostatin receptor in tumor diagnosis]. Duodecim 1996, 112:589-597.https://www.ncbi.nlm.nih.gov/pubmed/10592623
206. Parkkila AK, Parkkila S, Rajaniemi H: Carbonic anhydrase isoenzyme II is located in corticotrophs of the human pituitary gland. J Histochem Cytochem 1996, 44:245-250.https://www.ncbi.nlm.nih.gov/pubmed/8648084
207. Tsukamoto H, Horne W, Kamimura S, Niemela O, Parkkila S, Yla-Herttuala S, Brittenham GM: Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995, 96:620-630.https://www.ncbi.nlm.nih.gov/pubmed/7615836
208. Parkkila S, Parkkila AK, Rajaniemi H: Circadian periodicity in salivary carbonic anhydrase VI concentration. Acta Physiol Scand 1995, 154:205-211.https://www.ncbi.nlm.nih.gov/pubmed/7572216
209. Parkkila S, Parkkila AK, Juvonen T, Lehto VP, Rajaniemi H: Immunohistochemical demonstration of the carbonic anhydrase isoenzymes I and II in pancreatic tumours. Histochem J 1995, 27:133-138.https://www.ncbi.nlm.nih.gov/pubmed/7775197
210. Parkkila S, Niemela O: [Current aspects of alcohol-induced liver damage]. Duodecim 1995, 111:1194-1201.https://www.ncbi.nlm.nih.gov/pubmed/9221226
211. Parkkila S, Ahonen A, Torniainen P, Heikkila J, Salmela P: Detection of cervical metastases of thyroid medullary carcinoma by MoAb anti-CEA scintigraphy and immunohistochemistry. Eur J Nucl Med 1995, 22:1064-1068.https://www.ncbi.nlm.nih.gov/pubmed/7588944
212. Parkkila AK, Herva R, Parkkila S, Rajaniemi H: Immunohistochemical demonstration of human carbonic anhydrase isoenzyme II in brain tumours. Histochem J 1995, 27:974-982.https://www.ncbi.nlm.nih.gov/pubmed/8789398
213. Niemela O, Parkkila S, Yla-Herttuala S, Villanueva J, Ruebner B, Halsted CH: Sequential acetaldehyde production, lipid peroxidation, and fibrogenesis in micropig model of alcohol-induced liver disease. Hepatology 1995, 22:1208-1214.https://www.ncbi.nlm.nih.gov/pubmed/7557872
214. Kaunisto K, Parkkila S, Parkkila AK, Waheed A, Sly WS, Rajaniemi H: Expression of carbonic anhydrase isoenzymes IV and II in rat epididymal duct. Biol Reprod 1995, 52:1350-1357.https://www.ncbi.nlm.nih.gov/pubmed/7632842
215. Fleming RE, Parkkila S, Parkkila AK, Rajaniemi H, Waheed A, Sly WS: Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization. J Clin Invest 1995, 96:2907-2913.https://www.ncbi.nlm.nih.gov/pubmed/8675662
216. Parkkila S, Parkkila AK, Juvonen T, Rajaniemi H: Distribution of the carbonic anhydrase isoenzymes I, II, and VI in the human alimentary tract. Gut 1994, 35:646-650.https://www.ncbi.nlm.nih.gov/pubmed/8200558
217. Parkkila AK, Parkkila S, Serlo W, Reunanen M, Vierjoki T, Rajaniemi H: A competitive dual-label time-resolved immunofluorometric assay for simultaneous detection of carbonic anhydrase I and II in cerebrospinal fluid. Clin Chim Acta 1994, 230:81-89.https://www.ncbi.nlm.nih.gov/pubmed/7850996
218. Niemela O, Parkkila S, Yla-Herttuala S, Halsted C, Witztum JL, Lanca A, Israel Y: Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. Lab Invest 1994, 70:537-546.https://www.ncbi.nlm.nih.gov/pubmed/8176892
219. Muhlhauser J, Crescimanno C, Rajaniemi H, Parkkila S, Milovanov AP, Castellucci M, Kaufmann P: Immunohistochemistry of carbonic anhydrase in human placenta and fetal membranes. Histochemistry 1994, 101:91-98.https://www.ncbi.nlm.nih.gov/pubmed/8071088
220. Juvonen T, Rasanen O, Reinila A, Parkkila S, Nissinen J, Kairaluoma MI, Sormunen R, Niemela O: Segmental mediolytic arteritis–electronmicroscopic and immunohistochemical study. Eur J Vasc Surg 1994, 8:70-77.https://www.ncbi.nlm.nih.gov/pubmed/8307220
221. Juvonen T, Parkkila S, Parkkila AK, Niemela O, Lajunen LH, Kairaluoma MI, Peramaki P, Rajaniemi H: High-activity carbonic anhydrase isoenzyme (CA II) in human gallbladder epithelium. J Histochem Cytochem 1994, 42:1393-1397.https://www.ncbi.nlm.nih.gov/pubmed/7930522
222. Juvonen T, Parkkila S, Lepojarvi M, Niemela O: Demonstration of a bioactive elastin-derived peptide (Val-Gly-Val-Ala-Pro-Gly) in vascular lesions characterised by the segmental destruction of media. Ann Chir Gynaecol 1994, 83:296-302.https://www.ncbi.nlm.nih.gov/pubmed/7733613
223. Parkkila S, Rajaniemi H, Kellokumpu S: Polarized expression of a band 3-related protein in mammalian sperm cells. Biol Reprod 1993, 49:326-331.https://www.ncbi.nlm.nih.gov/pubmed/8373956
224. Parkkila S, Parkkila AK, Vierjoki T, Stahlberg T, Rajaniemi H: Competitive time-resolved immunofluorometric assay for quantifying carbonic anhydrase VI in saliva. Clin Chem 1993, 39:2154-2157.https://www.ncbi.nlm.nih.gov/pubmed/8403401
225. Parkkila S, Parkkila AK, Kaunisto K, Waheed A, Sly WS, Rajaniemi H: Location of a membrane-bound carbonic anhydrase isoenzyme (CA IV) in the human male reproductive tract. J Histochem Cytochem 1993, 41:751-757.https://www.ncbi.nlm.nih.gov/pubmed/8468457
226. Parkkila AK, Parkkila S, Juvonen T, Rajaniemi H: Carbonic anhydrase isoenzymes II and I are present in the zona glomerulosa cells of the human adrenal gland. Histochemistry 1993, 99:37-41.https://www.ncbi.nlm.nih.gov/pubmed/8468192
227. Halsted CH, Villanueva J, Chandler CJ, Ruebner B, Munn RJ, Parkkila S, Niemela O: Centrilobular distribution of acetaldehyde and collagen in the ethanol-fed micropig. Hepatology 1993, 18:954-960.https://www.ncbi.nlm.nih.gov/pubmed/8406371
228. Parkkila S, Kaunisto K, Kellokumpu S, Rajaniemi H: A high activity carbonic anhydrase isoenzyme (CA II) is present in mammalian spermatozoa. Histochemistry 1991, 95:477-482.https://www.ncbi.nlm.nih.gov/pubmed/1907954
229. Niemela O, Juvonen T, Parkkila S: Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption. J Clin Invest 1991, 87:1367-1374.https://www.ncbi.nlm.nih.gov/pubmed/1707062
230. Parkkila S, Kaunisto K, Rajaniemi L, Kumpulainen T, Jokinen K, Rajaniemi H: Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands. J Histochem Cytochem 1990, 38:941-947.https://www.ncbi.nlm.nih.gov/pubmed/2113069
231. Kaunisto K, Parkkila S, Tammela T, Ronnberg L, Rajaniemi H: Immunohistochemical localization of carbonic anhydrase isoenzymes in the human male reproductive tract. Histochemistry 1990, 94:381-386.https://www.ncbi.nlm.nih.gov/pubmed/2121671
232. Parkkila S, Rajaniemi H: Carbonic anhydrase activity in peripheral T-lymphocytes and appearance of the activity during their maturation in the thymus. A histochemical demonstration. Histochemistry 1989, 91:479-482.https://www.ncbi.nlm.nih.gov/pubmed/2475464